Inducing protein aggregation by extensional flow

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Inducing protein aggregation by extensional flow.

Relative to other extrinsic factors, the effects of hydrodynamic flow fields on protein stability and conformation remain poorly understood. Flow-induced protein remodeling and/or aggregation is observed both in Nature and during the large-scale industrial manufacture of proteins. Despite its ubiquity, the relationships between the type and magnitude of hydrodynamic flow, a protein's structure ...

متن کامل

Extensional Flow of Bulk Polymers

A standard Instron testing machine, in which crosshead displacement varies linearly with time was modified so that crosshead displacement varies exponentially with time. This change permits testing at constant Hencky strain rate (c = fi/8), which provides a constant stretch history for both simple extensional flow and strip biaxial extensional flow. This results in a visualization of the steady...

متن کامل

Extensional-flow-induced crystallization of isotactic polypropylene

A filament stretching extensional rheometer with a custom-built oven was used to investigate the effect of uniaxial flow on the crystallization of polypropylene. Prior to stretching, samples were heated to a temperature well above the melt temperature to erase their thermal and mechanical histories and the Janeschitz-Kriegl protocol was applied. The samples were stretched at extension rates in ...

متن کامل

Simulations of extensional flow in microrheometric devices

CEFT, Departmento de Engenharia Química, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal Department of Mechanical Engineering, MIT, 77 Massachusetts Avenue, Cambridge , MA 02139-4307, USA Department of Chemical and Biomolecular Engineering, The University of Melbourne, VIC 3010, Australia Email: [email protected], [email protected], [email protected], mm...

متن کامل

One hundred years of extensional flow ?

This historical review takes a few selected issues from the rheological studies of extensional flow that fill the literature, starting with extracts from the seminal papers of Trouton (Proc. Roy. Soc. A77 (1906) 426-440) and Fano (Archivio di fisiologio, 5 (1908) 365-370). Work in the first half of the twentieth century on spinnability and extensional viscosity measurement is highlighted, follo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2017

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1702724114